1. It can be prepared via a Grignard reaction between ethylmagnesium bromide and piperonylonitrile. 2. The modern method employs the Grignard reaction , using phenylmagnesium bromide and SbCl 3. 3. The Grignard reaction is an important means of preparing organic compounds from smaller precursor molecules. 4. Secondly, Grignard reactions , while exothermic, are typically conducted at low temperature for better selectivity. 5. This synthesis was the best way to make alcohols until the advent of the Grignard reaction in 1901. 6. The apparent increased reactivity of hypervalent molecules, contrasted with tetravalent analogues, has also been observed for Grignard reactions . 7. The Grignard reaction does not have this advantage because it is so reactive that it attacks indiscriminately from both sides. 8. The most common application of Grignard reagents is the alkylation of aldehydes and ketones, i . e . the Grignard reaction : 9. For instance in the E1cB elimination reaction and in organometallic chemistry in for instance a Grignard reaction or in alkyl lithium chemistry. 10. A synthesis of tolcapone proposed in 2008 begins with a Grignard reaction between a benzaldehyde derivative and p-tolyl magnesium bromide.
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